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1. Design and production of genetically modified soybean protein with anti-hypertensive activity by incorporating potent analogue of ovokinin (2-7) (FEBS Letters 24860 (2001) 1-5
   Nobuyuki Matoba, Naomi Doyama, Yuko Yamada, Nobuyuki Maruyama, Shigeru Utsumi,  Masaaki Yoshikawa
   Research Institute For Food Science,  Kyoto University,  Uji  Kyoto 611-0011, Japan
   Animal used : SHR
   

2. Design of a Highly Potent Anti-hypertensive Peptide Based on Ovokinin(2-7) (Biosci. Biotechnol. Biochem.,66(6), 1213-1217,2002)
   Yuko Yamada, Nobuyuki Matoba, Hachiro Usui, Kunihiko Onishi, and Masaaki Yoshikawa
   Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan
   Animal used : SHR and Wky Rat
   

3. Syndecan-4 Deficiency Leads to High Mortality of Lipopolysaccharide-injected Mice (The Journal of Biological Chemistry, Vol. 276, No. 50, Issue of December 14, pp. 47483-47488, 2001)
   Kazuhiro Ishiguro?ö?˜,  Kenji Kadomatsu?ö?÷,  Tetsuhito Kojima?ö?÷||,  Hisako Muramatsu?ö,  Mitsunori Iwase||,
   Yasunobu Yoshikai**,  Masamitsu Yanada?ö?˜,  Koji Yamamoto?˜, Tadashi  Matsushita?˜,  Masahiko Nishimura?ö?ö
   Kazuo Kusugami?˜,  Hidehiko Saito?˜ ?˜?˜,  and Takashi Muramatsu?ö?÷?÷
   From the ?öDepartment of Biochemistry, ?˜First Department of Internal Medicine, **Laboratory of Host Defense & Germfree Life, Research Institute for Disease Mechanism and Control, and ?ö?öInstitute for Laboratory Animal Research, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan, the ||Department of  Medical Technology, Nagoya University School of Health Sciences, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673,Japan, and the ?˜?˜Nagoya National Hospital, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi, 460-0001, Japan
   

4. Validity and Application of Noninvasive Measurement of Blood Pressure in Hamsters (Exp.Anim. 52(4), 359-363, 2003)
   Kato Y,  Iwase M,  Kanazawa H,  Nishizawa T,  Zhao YL,  Takagi K,  Nagata K,  Noda A,  Koike Y,  Yokota M
   School of Health Sciences, Nagoya University, 1-1-20 Daiko-minami, Higashi-ku, Nagoya 461-8673, Japan.
   

5. Progressive Development of Pulmonary Hypertension Leading to Right Ventricular Hypertrophy Assessed by Echocardiography in Rats (Exp. Anim. 52(4), 285-294, 2003)
   Yosuke KATO1), Mitsunori  IWASE1), Hiroaki  KANAZAWA1),  Natsuki  KAWATA1) ,Yukie YOSHIMORI,1)
   Katsunori HASHIMOTO1),  Toyoharu YOKOI1),  Akiko NODA1),  Kenzo TAKAGI1),  Yasuo KOIKE1),
   Takao NISHIZAWA2),  Masahiko NISHIMURA2), and Mitsuhiro YOKOTA2)
   1)School of Health Science, Nagoya University,1-1-20 Daiko-minami,Higashi-ku, Nagoya 461-8673, and,
   2)Graduate School of Medicine, NagoyaUniversity,65 Tsurumai-cho, Showa-ku,Nagoya 466-8550,Japan
   

6. Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth (The Journal of Clinical Investigation July 2003 Vol.112, No. 1)
   Kimiyasu Egami,1,2 Toyoaki Murohara,1,3,4 Toshifumi Shimada,1,3 Ken-ichiro Sasaki,1,3
   Satoshi Shintani,1,3 Takeshi Sugaya,5 Masahiro Ishii,1,2 Teiji Akagi,1,2 Hisao Ikeda,1,3
   Toyojiro Matsuishi,1,2 and Tsutomu Imaizumi1,3
   1 The Cardiovascular Research Institute,
   2 Department of Pediatrics, and
   3 Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
   4 Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
   5 Discovery Research Laboratory, Tanabe Seiyaku Co., Osaka, Japan
   Animal used : C57BL6 Mouse
   

7. Growth hormone-releasing peptide can improve left ventricular dysfunction and attenuate dilation in dilated cardiomyopathic hamsters  (Cardiovascular Research 61 (2004) 30-38)
   Iwase, M., Kanazawa, H., Kato, Y., Nishizawa, T., Somura, F., Ishiki, R., Hagata, K., Hashimoto, K., Takagi, K., Izawa, H. and Yokota,
   

8. Development of an in vivo Bioassay Method for Allergy-Preventive Substances using HEL-induced Blood Flow Decrease (Biol. Pharm. Bull)
   Kyoko Ishiguro1), Hisae Oku1), Yoshimi Ueda1), Emiko Iwaoka1) and Masaru Kunitomo1)
   1) School of Pharmaceutical Sciences, Mukogawa Women's University
   Animal used : ddY Mouse
   

9. Salt-sensitive hypertension is triggered by Ca²⁺ entry via Na⁺/Ca²⁺ exchanger type-1 in vascular smooth muscle (NATURE MEDICINE Volume 10 Number 11  November 2004)
   Takahiro Iwamoto1,3, Satomi Kita1,5, Jin Zhang2, Mordecai P Blaustein2, Yuji Arai4, Shigeru Yoshida5,
   Koji wakimoto6, Issei Komuro7&Takeshi Katsuragi1
   1 Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
   2 Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
   3 Department of Molecular Physiology, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan.
   4 Department of Bioscience, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan.
   5 Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama 330-8530, Japan.
   6 Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka 532-8505, Japan.
   7 Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
   Animal used : C57BL6 Mouse
   

10. The vascular relaxing effects of sevoflurane and isoflurane are more important in hypertensive than in normotensive rats (Canadian Journal of Anesthesia 51: 979-985, 2004)
    Jingui Yu, MD*, Koji Ogawa, MD, Yasuyuki Tokinaga, MD*, Shizue Iwahashi, MD* and Yoshio Hatano, MD*
    * From the Department of Anesthesiology, and the Surgical Operating Center, Wakayama Medical University, Wakayama City, Japan.
    

11. Angiogenesis and Vasculogenesis Are Impaired in the Precocious-Aging klotho Mouse(American Heart Association  Circulation. 2004;110:1148-1155.)
    Toshifumi Shimada, MD; Yoshiaki Takeshita, MD; Toyoaki Murohara, MD; Ken-ichiro Sasaki, MD;
    Kimiyasu Egami, MD; Satoshi Shintani, MD; Yosuke Katsuda, MD; Hisao Ikeda, MD;
    Yo-ichi Nabeshima, MD; Tsutomu Imaizumi, MD
    From the Cardiovascular Research Institute (T.S., Y.T., T.M., K.-i.S., K.E., S.S., Y.K., H.I., T.I.), Kurume University, Kurume; the Department of Cardiology (T.M.), Nagoya University Graduate School of Medicine, Nagoya; and the Department of Pathology and Tumor Biology (Y.-i.N.), Kyoto University Graduate School of Medicine, Kyoto, Japan.
    

12. Effects of Captoprill on Cardiac and Renal Damage, and Metabolic Alterations in the Nitric Oxide-Deficient Hypertensive Rat (Kidney Blood Pressure Research 2005; 28: 243-250)
    Mahmoud M. Khattab Adel Mostafa Othman Al-Shabanah
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh , Saudi Arabia
    

13. Rat Phenome Project: The untapped potential of existing rat strains  (J Appl Physiol 98: 371-379, 2005)
    Tomoji Mashimo, Birger Voigt, Takashi Kuramoto, and Tadao Serikawa
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    

14. An X-Ray Diffraction Study on Mouse Cardiac Cross-Bridge Function In Vivo: Effects of Adrenergic ß-Stimulation (Biophysical Journal 90:1723-1728 (2006)
    Ryuji Toh,* Masakazu Shinohara,* Tomofumi Takaya,* Tomoya Yamashita,* Shigeru Masuda,*
    Seinosuke Kawashima,* Mitsuhiro Yokoyama,* and Naoto Yagiy
    *Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine,Kobe 650-0017, Japan; and ySPring-8/JASRI, Sayo, Hyogo 679-5198, Japan
    

15. Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice (Am J Physiol Lung Cell Mol Physiol 290: L59-L65, 2006.)
    Shinsuke Murakami,1,2 Noritoshi Nagaya,1,3 Takefumi Itoh,2 Masaharu Kataoka,1 Takashi Iwase,1
    Takeshi Horio,3 Yoshinori Miyahara,4 Yoshiki Sakai,5 Kenji Kangawa,6 and Hiroshi Kimura2
    1Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research
    Institute, Osaka; 2Second Department of Internal Medicine, Nara Medical University, Nara; 3Department of
    Internal Medicine, National Cardiovascular Center, Osaka; 4Department of Cardiac Physiology, National
    Cardiovascular Center Research Institute, Osaka; 5Ono Pharmaceutical Co., Ltd. Research Headquarters,
    Osaka; and 6Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan
    

16. Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitory Peptide Obtained from Hen Ovotransferrin (Journal of the Chinese Chemical Society, 2006, 53, 495-501)
    Nai-Yuan Leea, Juei-Tang Chengb, Toshiki Enomotoc, Ichiro Nakamurad,
    a Livestock Research Institute, Tainan 712, Taiwan, R.O.C.
    b Department Pharmacology, College of Medicine, National Cheng Kung University,
       Tainan 70101, Taiwan, R.O.C.
    c Department of Food Science, Ishikawa Prefectural University, Nonoichi, Ishikawa 9218836, Japan
    d Institute of Animal Experimentation, School of Medicine, Hokkaido University, Sapporo 0608589, Japan
    Animal used : SHR
    

17. Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats (Biol. Pharm. Bull. 29(8) 1756-1758 (2006) Vol. 29, No. 8
    KUBOTA Yoko1 UMEGAKI Keizo2 KAGOTA Satomi 3 TANAKA Naoko 4 NAKAMURA Kazuki 5 KUNITOMO Masaru 6 SHINOZUKA Kazumasa 7
    1 Department of Biopharmaceutics, Nihon Pharmaceutical University
    2 National Institute of Health and Nutrition
    3 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
    4 Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
    5 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
    6 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
    7 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
    

18. Mechanical ventilation with 40% oxygen reduces pulmonary expressionof genes that regulate lung development and impairs alveolar septation in newborn mice
    (Am J Physiol Lung Cell Mol Physiol 293:1099-1110, 2007. )
    Richard D. Bland, Lucia M. Mokres, Robert Ertsey, Berit E. Jacobson, Shu Jiang, Marlene Rabinovitch,
    Liwen Xu, Eric S. Shinwell, Feijie Zhang, and Matthew A. Beasley
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California
    

19.  Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of  
       newborn mice.
      (Am J Physiol Lung Cell Mol Physiol 294:L3-L14, 2008. )
     Richard D. Bland, Robert Ertsey, Lucia M. Mokres, Liwen Xu, Berit E. Jacobson, Shu Jiang,
     Cristina M. Alvira, Marlene Rabinovitch, Eric S. Shinwell, and Anjali Dixit
        Department of Pediatrics, Stanford University School of Medicine, Stanford, California


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